Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply

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Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply
Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply

Product Images

Product Features

  • Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age
  • Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
  • Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours
  • Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age
  • Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
  • Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours

Product Specifications

Item Weight 1.6 ounces
Department Flea & Tick
Manufacturer Elanco US Inc
ASIN B004QMX59Q
Item model number 86336685
Date First Available December 20, 2002
Item Package Dimensions L x W x H 6.61 x 4.33 x 1.44 inches
Item Dimensions LxWxH 1.38 x 4.38 x 6.63 inches
Item Weight 0.1 Pounds
Brand Name Advantage
Target Audience Keyword dogs
Directions Application Instructions: 1. Use only on dogs. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. 5. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. 6. Do not apply an excessive amount of solution at any one spot that could cause the solution to run off the side of the dog. 7. Do not get this product in your dog’s eyes or allow them to ingest.
Country of Origin Germany
Model Name Advantage II
Color Blacks & Grays
Size 6-Pack
Material Cotton
Age Range Description 7 weeks and older
Care Instructions Topical Treatment
Number of Items 6
Manufacturer Elanco US Inc
Style Large Dog
Breed Recommendation Large
Specific Uses for Product Parasites

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Related Product Deals & User Reviews

  1. Kills fleas well normally, but some seasons fleas are particular difficult to control. This is a bad flea year for my area. I have used this product for years on my dogs & can normally go as long as up to 8 weeks between doses. I have noticed that on some years (2014 & 2011) that the fleas are particular difficult to control. I know it is not due to this product not being effective because I have treated my yard with 2 different products that normally work very well within a 10 day period & even those products have made very little difference in the fleas. I have treated my dogs at 9 days & repeated again at 13 days. I am also using natural flea shampoo & topical sprays with essential oils. The fleas do die within 12 hours, but by that time my dog with allergies is a mess due to bites before they die. I am now seeing primarily very tiny fleas which tells me that I am achieving some control over the adult fleas. I dislike giving doses that close together, but that is what the insert recommends (actually every 7 days until controlled) for heavy flea infestations. One of my dogs has terrible flea allergies. He has been miserable & has been on prednisone & benadryl for over a month. I don’t even like for him to be outdoors because they are so bad. I have to pick fleas off both dogs every time they step outside. I don’t have any carpet in my home so I know they are not living in my house. It just seems that some years the fleas are just almost impossible to control. I am in Savannah, Ga. Last summer, the fleas were no problem at all. I did not even treat my lawn. I only gave Advantage every 6-8 weeks. The summer of 2011 was also a bad flea year. I’m not sure what is the cause, probably something to do with the weather or maybe they just have cyclic bad years (who knows). I thought this would be a mild year for fleas because the winter was so cold, but that apparently is not true. I have learned that unfortunately on bad flea years it will take a few months to get the fleas under control even using multiple products. Nothing much else you can do, but suffer until they are under control!!……………Update: After treating my yard with 2 different products within a month & treating my dogs with 3 doses (once every 10 days), the fleas appear to finally be under control. No fleas for 3 days!!! Allergic dog is finally getting some relief. Hopefully, I can now only treat my dogs monthly since I have gotten the severe flea infestation under control. It just takes a while to break the flea life cycle if you have a severe infestation…………..UPDATE…Fleas are finally under control. Have not had to re-apply for 4 weeks. Just had a small flea on my allergic dog. Will re-apply today. Once you break the flea life cycle this will control the fleas. I buy the large dog size package & draw out the dosage for each dog with a blunt tip syringe. This is more cost effective & I have found that I can control the fleas by using a smaller dosage for my 30lb dog with allergies. The size package for his weight is a 2.5ml dose (weight range 21-55 lbs). He only weighs 30lbs & the weight limit is a very broad range for his size. The next smaller size range (10 to 20 lbs) is 1.0 ml so at approximately 0.5ml per 10 lbs, I don’t feel he needs the entire 2.5ml dose & I have found that he does not. I normally am able to give him only 1.5 to 2.0 ml which will work fine once the severe infestation is under control. I don’t like having to give chemicals to my dog & the less the better. He also has skin problems & the Advantage does seem to flare up his skin problems, so less is better. I am also able to give my cat a dose if he happens to pick up an untreated flea (he is an inside cat, but he will occasionally sneak out if he can). The Advantage is the same ingredients for dogs & cats (also confirmed with my vet), but the Advantix is NOT. DO NOT give Advantix to cats!

  2. Our success story. I know there are A-LOT of bad reviews for these but my belief is that people are using the product wrong, possibly issuing wrong doses or ordering the wrong product size. Bayer is a local, well known, trusted company in my area and I can tell you that they do not manufacture products that would kill your animals or harm them. This is a local, USA company. I have had family members that have worked for them their entire lives.Now on to the product. It works very well. We were using Frontline but it did not work. AT ALL. Our dog was getting ticks, our cats and dog had fleas. We used Frontline religiously and it just didn’t perform. We ended up with a really bad flea infestation in our home and we needed to take action as multiple flea baths and house treatment were not helping. We finally switched to advantage II. Weary about the reviews we applied it to our animals in the proper dosage, size, and areas. Read, read and re-read the instructions. There are specific ways to apply this for specific animals. There are also specific sizes that you purchase depending on the type and weight of your animal. YOU NEED TO READ! Within two weeks after we treated our house with products known as permethrin and I.G. regulators as well as using Bayer Advantage II we completely got rid of our flea problem. Its now been months since we have had the problem and we haven’t found a single flea on our animals. This stuff just hands down works. I would recommend to anybody and I’m going to keep purchasing it because I never want to have fleas in my home again. Its well worth the price.UPDATE: Its now been 5 years since my original review and we still use this. We have not had a single flea issue since my original review. Our animals are safe and healthy. Be aware that there are counterfeits on Amazon. There are articles on the internet of what to check for. If you are concerned, purchase it from your vet or Chewy.

  3. Our success story. I know there are A-LOT of bad reviews for these but my belief is that people are using the product wrong, possibly issuing wrong doses or ordering the wrong product size. Bayer is a local, well known, trusted company in my area and I can tell you that they do not manufacture products that would kill your animals or harm them. This is a local, USA company. I have had family members that have worked for them their entire lives.Now on to the product. It works very well. We were using Frontline but it did not work. AT ALL. Our dog was getting ticks, our cats and dog had fleas. We used Frontline religiously and it just didn’t perform. We ended up with a really bad flea infestation in our home and we needed to take action as multiple flea baths and house treatment were not helping. We finally switched to advantage II. Weary about the reviews we applied it to our animals in the proper dosage, size, and areas. Read, read and re-read the instructions. There are specific ways to apply this for specific animals. There are also specific sizes that you purchase depending on the type and weight of your animal. YOU NEED TO READ! Within two weeks after we treated our house with products known as permethrin and I.G. regulators as well as using Bayer Advantage II we completely got rid of our flea problem. Its now been months since we have had the problem and we haven’t found a single flea on our animals. This stuff just hands down works. I would recommend to anybody and I’m going to keep purchasing it because I never want to have fleas in my home again. Its well worth the price.UPDATE: Its now been 5 years since my original review and we still use this. We have not had a single flea issue since my original review. Our animals are safe and healthy. Be aware that there are counterfeits on Amazon. There are articles on the internet of what to check for. If you are concerned, purchase it from your vet or Chewy.

  4. Convenient and good for pest control. I’ve used advantage II for years and get it from Amazon at a much better price that from the vets. But it seems to not be doing a good a job that it has in the past. I just got a new box of 6 and will see. I don’t know what I will get to replace it if it has stopped working, so will keep my fingers crossed that maybe I just got a weak batch. There is no expiration date on any of the boxes, just a code, and the manufacturer won’t give you the date in normal month/year format because they are not required to by law. Also, the box I just received today was opened, and the side fold at the top was ripped (not by me) but of course, the individual tubes are sealed up in mylar so I don’t worry they have been tampered with, but that it was unusual. All in all a good product, but I am watching it!

  5. Convenient and good for pest control. I’ve used advantage II for years and get it from Amazon at a much better price that from the vets. But it seems to not be doing a good a job that it has in the past. I just got a new box of 6 and will see. I don’t know what I will get to replace it if it has stopped working, so will keep my fingers crossed that maybe I just got a weak batch. There is no expiration date on any of the boxes, just a code, and the manufacturer won’t give you the date in normal month/year format because they are not required to by law. Also, the box I just received today was opened, and the side fold at the top was ripped (not by me) but of course, the individual tubes are sealed up in mylar so I don’t worry they have been tampered with, but that it was unusual. All in all a good product, but I am watching it!

  6. Convenient and good for pest control. I’ve used advantage II for years and get it from Amazon at a much better price that from the vets. But it seems to not be doing a good a job that it has in the past. I just got a new box of 6 and will see. I don’t know what I will get to replace it if it has stopped working, so will keep my fingers crossed that maybe I just got a weak batch. There is no expiration date on any of the boxes, just a code, and the manufacturer won’t give you the date in normal month/year format because they are not required to by law. Also, the box I just received today was opened, and the side fold at the top was ripped (not by me) but of course, the individual tubes are sealed up in mylar so I don’t worry they have been tampered with, but that it was unusual. All in all a good product, but I am watching it!

  7. Style and color. I like the color I like the sock like top I took out the insole and use the insoles from a different brand of shoe and it’s fine. And I like the airy part of it that’s cooling. I would buy them again

  8. Tubby Beagle. The Beage is 43 lbs (we’re working in it, bought a cat door) …Anyway, product killed fleas…they were beyond lethargic within 60 mins and after the 1st week there was zero live or dead in the bath…🤷🏻‍♂️…oh and he had no ill side affects…Thanks for a great product

  9. Works Well. Excellent flea repellant, have not had any issues ~ and I regularly comb through my puppy’s coat thoroughly.

  10. Kills fleas. Great price and does the job! We have four dogs and it’s always cheaper to order online. This is easy to apply, doesn’t harm the dog, & kills fleas. What more could you ask for?!?

  11. Allan M. Shanberg MD August 30, 2023 at 12:00 am

    my dog likes it. easy to use for her

  12. Advantage 2 is the best!!! 👌. I only get Advantage 2 aa it works the best in my experience. My 3 year old fawn colored female American Pitbull Terrier started whining & itching so I checked her and she had fleas. Within a few days of putting this on my girl all her fleas are gone and haven’t came back. It’s so easy to use and has durability as it won’t wash off. It doesn’t smell bad and there are no bad side effects. I highly recommend it and make sure you get it from Amazon because it’s so much cheaper. It’s almost twice the price at petsmart and petco!

  13. Simply the BEST! It Works Great and Doesn’t Bother the Dog at All. It took us several years to finally get a flea product that actually worked as advertised. This is it folks. Save yourself the trouble and aggravation of trying to find a flea product for your dog that actually works. This is the one! Granted, it’s not cheap but it works to continually kill fleas and their eggs so your dog(s) won’t be scratching, and your house will stay free of fleas! Do yourself and your pets a favor and purchase this Advantage II Flea Treatment and Prevention product! Nothing works as well!

  14. Simply the BEST! It Works Great and Doesn’t Bother the Dog at All. It took us several years to finally get a flea product that actually worked as advertised. This is it folks. Save yourself the trouble and aggravation of trying to find a flea product for your dog that actually works. This is the one! Granted, it’s not cheap but it works to continually kill fleas and their eggs so your dog(s) won’t be scratching, and your house will stay free of fleas! Do yourself and your pets a favor and purchase this Advantage II Flea Treatment and Prevention product! Nothing works as well!

  15. Simply the BEST! It Works Great and Doesn’t Bother the Dog at All. It took us several years to finally get a flea product that actually worked as advertised. This is it folks. Save yourself the trouble and aggravation of trying to find a flea product for your dog that actually works. This is the one! Granted, it’s not cheap but it works to continually kill fleas and their eggs so your dog(s) won’t be scratching, and your house will stay free of fleas! Do yourself and your pets a favor and purchase this Advantage II Flea Treatment and Prevention product! Nothing works as well!

  16. This product works and reasonably priced. Working great! I have not seen any fleas or ticks and they DO NOT scratch ever! Definitely will buy again

  17. Worked in 2 days. I put this on my dog and within 2 days the fleas were pretty much off him.

  18. Great product, fast shipping. Great product, fast shipping

  19. Not sure. Not sure If it works I used a flea comb 3timesAnd no fleas. So I guess it’s working. But he isStill scratching. No smell easy to apply.

  20. Worked perfectly. Within 24 hours of application, all the fleas were gone!

  21. Worked perfectly. Within 24 hours of application, all the fleas were gone!

  22. wendy de la cruz January 27, 2025 at 12:00 am

    its good. Works super well i used it once and my dog’s fleas were finally gone life saver

  23. No fleas, no ticks. Works for all 3 of my dogs, no fleas, no ticks! I buy this product every summer!

  24. Works well. I have never had a problem getting rid of fleas with Advantage

  25. Great job. Great job

  26. A Helpful Tool In Our Flea Control Regimen. We have double coated, long haired, very furry large Northern Breed Mixed Dogs. Unfortunately, fleas are a year round problem here in the San Francisco Bay Area where we live … Ugh!Advantage II Topical Flea Treatment & Prevention is an effective tool in our flea control regimen.- Easy to apply the topical drops on your dog’s skin along the backbone.- Our dogs have never had any skin irritation or other negative reactions with this product.- The 6 pack is a terrific value.I highly recommend this product.

  27. Amazon Customer January 5, 2026 at 12:00 am

    Works Great. While others claimed to rid fleas this one actually delivered control within 72 hours of application

  28. Seresto Flea collars are life changing for pets and owner💯. Life Changing Flea Collars that really do last 8 months. No more battling fleas! Retired Rescue and breeder of 30 years. Seresto Flea collars are the only way and no fleas or ticks ever again.

  29. Mary Rae Fouts March 8, 2026 at 12:00 am

    It’s effective without being too potent. I’ve been using this for years. It works pretty good. It’s becoming less and less effective as the fleas evolve to it. But right now it’s still pretty effective.

  30. Happy Dog Lady March 8, 2026 at 12:00 am

    Great flea control. This product works very well for my animals

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